Class 1 Integron gene harbouring multidrug resistant Pseudomonas isolates from clinical specimen

Gram-negative Pseudomonas spp. particularly P. aeruginosa is an important pathogen in hospitalized patients, contributing to the morbidity and mortality due its multiple resistance mechanisms. The present study was undertaken determine characteristics of isolated from pus patients admitted a local diagnostic center, Dhaka, Bangladesh. A total 14 clinical isolates were obtained. Detailed biochemical tests, antibiotic pattern class 1 integron gene profiling successfully performed. All (100%) showed against amoxicillin-clavulanate, ampicillin, ciprofloxacin, cephalexin, ceftriaxone, kanamycin, nitrofurantoin rifampicin. About 35% (n=5) Amoxicillin-clavulanate, azithromycin, amikacin, co-trimoxazole, imipenem, Only 28.5% (n=4) sensitive Imipenem. Plasmid observed none isolates, whereas 50% carried Class Integron gene. presence mobile genetic element added threat as this enables transfer genes isolates. findings are significant public health viewpoint therapeutic options become restricted.
 Bangladesh J Microbiol, Volume 39, Number 1, June 2022, pp 15-19